Publication
Neurochemical research 50, 1, 28-28 (2025)
Dimethyl Fumarate Reduces Methylglyoxal-derived Carbonyl Stress Through Nrf2/GSH Activation in SH-SY5Y Cells.
Author
Shin Koike, Satori Tsurudome, Saki Okano, Atsushi Kishida, Yuki Ogasawara
Category
Original Paper
Abstract
Dimethyl fumarate, a known Nrf2 activator, has been shown to alleviate carbonyl stress in neurons. It is currently used as a therapeutic agent for multiple sclerosis, and it is expected to be applied to the treatment of neurodegenerative diseases involving carbonyl stress in the future.