Publication

Previous studies have shown that polysulfides and persulfides protect neurons from oxidative and carbonyl stress. On the other hand, the role of polysulfides in response to endoplasmic reticulum stress was unknown. In this study, we found that polysulfide-induced activation of sensor proteins in the UPR (unfolded protein response) pathway induces the expression of Sestrin2 protein, and this mechanism protects cells from dicarbonyl compound-induced damage. The clarification of the mechanism of polysulfide-mediated activation of the UPR pathway and its cytoprotective role is expected to elucidate new pathogenic mechanisms of diseases involving carbonyl stress and endoplasmic reticulum stress in the future.