Our research has forcused on the biological sulfur component "sulfan sulfur," which was defined in the early 1970's. 

In 1993, we found that hydrogen sulfide is physiologically produced in mammals from cysteine. However, the amount of free hydrogen sulfide is minimal. Most of it exists in an unstable state bound to other sulfur atoms, which we defined as "bound sulfur. In the 21st century, hydrogen sulfide has attracted worldwide attention as a third gas in biological systems and various reports on its physiological functions have been made.

However, we have been researching hydrogen sulfide, considering that some of its functions are not caused by hydrogen sulfide gas but by bound sulfur (sulfane sulfur). We are currently focusing on the physiological significance of bound sulfur and developing a new general-use measurement method. We will attempt to analyze its application to various diseases.